Why use a tissue microarray?
Tissue microarray (TMA) can be used as a valuable, high-throughput diagnostic method. Allowing researchers to analyse several hundred different samples using just one paraffin block, a TMA can bring major economies in both time and consumables the cost to your research project. Advantages to using a TMA include:
- Increased tumour DNA content by targeting localised tumour areas
- Multiple tissue cores on one slide increases viewing efficiency allowing expeditious interpretation/screening of ancillary tests applied
- Reduces tissue requirements by removing the need for whole tissue sections
- Cost effective by reducing probe/antibody and sectioning requirements
- Improves accuracy of tumour tissue selection for genetic studies
- Ensures identical slide conditions, reducing slide to slide variability
TMA at HCB
HCB operates a TMA Grand Master, the first of its kind in the Southern Hemisphere and the only bespoke TMA platform of this quality currently in operation. This investment has elevated TMA workflow to a new level.
Our tissue microarrays are generated with the fastest and highest capacity TMA platform, allowing for superior precision in the selection and extraction of specific regions of interest. Core diameters range from 0.6 to 2mm, with a capacity of over 500 cores per block for 0.6mm cores.
We also have the capacity to extract tissue samples to standard 0.2ml PCR tubes for DNA extraction or similar work.
All tissue microarrays are created in consultation with, and validated by, the biobank pathologist to ensure that they are of exceptional quality and tailored to specific research aims. For maximum research utility, all tissue cores are annotated with clinical data which can be customised or filtered on request.
Our TMAs are an affordable option at 25% the cost per slide of other national and international TMA providers and can be created using HCB banked tissue, or tissue provided from your own collections.
For further examples of our TMAs, please visit our Virtual Biobank page.
The University of Newcastle acknowledges the traditional custodians of the lands within our footprint areas: Awabakal, Darkinjung, Biripai, Worimi, Wonnarua, and Eora Nations. We also pay respect to the wisdom of our Elders past and present.